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Journal of Case Reports
Role of Autologous Adipose derived Mesenchymal Stem Cells and Platelet Rich Plasma in Knee Osteoarthritis
Anant Marathe, Jaymesh Thadani1, Prashant Kshatriya, Shivani Vakodikar, Rajni Vyas
Total Potential Cells (P) Ltd; 1Department of Zoology, Faculty of Science, The M.S.University of Baroda, Vadodara, Gujarat; India.
Corresponding Author:
Dr. Anant Marathe
Email: dranantmarathe@hotmail.com 
Received: 15-AUG-2017 Accepted: 13-OCT-2017 Published Online: 25-NOV-2017
DOI: http://dx.doi.org/10.17659/01.2017.0103
Abstract
Background: Conventional treatments of osteoarthritis demonstrate only modest clinical benefits without lesion reversal. Autologous mesenchymal stem cells (MSCs) are known to have potential for articular cartilage regeneration. We assess the feasibility and safety of treating osteoarthritis autologous MSCs in combination with platelet rich plasma (PRP). Material & Methods: Patients with chronic knee pain unresponsive to conservative treatments and showing radiological evidence of osteoarthritis were enrolled and injected adipose derived mesenchymal stem cells intra-articularly. The MSC-treated patients displayed significant improvement with Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) score. No adverse events related local or systemic were found. Conclusion: Autologous MSC therapy may be a valid alternative for the treatment of chronic knee osteoarthritis. 
Keywords : Intra-articular Injections, Regeneration, Knee Osteoarthritis, Mesenchymal Stromal cells, Pain.
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