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Journal of Case Reports
Sodium Valproate as a Probable Cause of Gut Gangrene: Report of Two Unusual Cases
Jitendra Singh, Satish Dalal, Chisel Bhatia, Amiraj Singh, Jagatpal Beniwal
Department of General Surgery, Pt. B. D. Sharma Postgraduate Institute of Medical Sciences (P.G.I.M.S.), Rohtak-124001, Haryana, India.
Corresponding Author:
Dr. Jitendra Singh
Email: jitenderasingh742@gmail.com
Received: 17-JUL-2018 Accepted: 19-SEP-2018 Published Online: 15-DEC-2018
DOI: http://dx.doi.org/10.17659/01.2018.0076
Background: Gangrenous gut is a highly fatal condition most often caused by mesenteric ischemia or intestinal obstruction and requires emergency surgical intervention. There is no definite evidence about role of anti-epileptics as a cause of gut gangrene. Case Report: We encountered two patients who presented with gangrenous bowel and both patients had history of treatment of sodium valproate. There was no other evident cause for gut gangrene in these patients. Conclusion: Hence, with this case report we discuss and emphasize that sodium valproate can be a probable cause for gut gangrene in patients who are undergoing treatment with this agent.
Keywords : Anticonvulsants, Gangrene, Intestinal Obstruction, Mesenteric Ischemia, Valproic Acid.
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