Background: Sympathetic ganglion block have been shown to supply immediate relief in various type of chronic pain, but to best of our knowledge, cleaning up of psoriatic lesions after sympathetic ganglion blockage has rarely been reported. Case Report: A 64-year-old patient who has been suffering from chronic pain and plaque psoriasis underwent lumbar and stellate ganglion block in our facility. After the successful treatment, the patient was relieved from pain and psoriatic lesions. Sympathetic ganglion block have been shown to supply immediate relief in various type of chronic pain, but to best of our knowledge, cleaning up of psoriatic lesions after sympathetic ganglion blockage has rarely been reported. Conclusion: We describe a case report in which sympathetic ganglion block successfully treated both chronic pain and plaque psoriasis in a pharmacologically non-responsive patient.