Background: Jaundice is a common clinical presentation with diverse causes. Although acute Epstein–Barr virus (EBV) infection usually causes mild hepatitis, secondary hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening complication. Jaundice as the presenting feature of EBV-associated HLH in adults is uncommon. Case Report: A 23-year-old man presented with fever, progressive jaundice, dark urine, sore throat, and severe anemia. Investigations revealed hyperbilirubinemia, transaminitis, hemolysis, markedly elevated inflammatory markers, hyperferritinemia, and hypertriglyceridemia. Common infectious and hematological causes were excluded. High-resolution computed tomography showed atypical bilateral pneumonia, and EBV IgM serology was positive. Based on the clinical and laboratory findings, a diagnosis of EBV-associated secondary HLH was made. The patient improved with supportive care, antibiotics, respiratory support, and blood transfusions, and was discharged in stable condition. Conclusion: This case highlights the importance of considering EBV-associated HLH in adults presenting with unexplained jaundice, hemolytic anemia, and systemic inflammation. Early diagnosis and prompt management can lead to favourable outcomes despite this rare presentation.